BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK signaling cascade, a signal transduction pathway that transmits mitogenic ...

A BRAF mutation is a form of cancer in which the BRAF gene begins to cause certain cells to continue dividing without ever receiving a signal to stop. The V600E variant is one of the more common ...

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma. Our work on the gene and the structure of the BRAF protein ...

BRAF V600E-mutated colorectal cancer represents ... At the same time, the interim overall survival signal also provided the FDA extra comfort.

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause ... As we have reported, the BRAF and RAS mutant tumors are more sensitive to ERK ...