Newsweek Sports' expert predictions for Detroit Lions vs. San Francisco 49ers on Monday Night Football Week 17.

Listing our expert Penn Live picks of the best prop bets and odds available for tonight's Monday Night Football NFC matchup between the Lions and 49ers.

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Micah Roberts has revealed his NFL Monday Night Football bets and NFL picks against the spread for Detroit vs. San Francisco

SportsLine expert Jimmie Kaylor shares his Week 17 NFL DFS picks, stacks, sleepers, rankings, values, lineups and player pool for 49ers vs. Lions on MNF

The Lions and 49ers kick off tonight at 5:15 p.m. PT (8:15 p.m. ET) on ABC, ESPN and ESPN Plus. Looking for the ManningCast? The Manning brothers have the night off; Peyton and Eli won't return until next month for a Wild Card game.

The Detroit Lions seek revenge and the NFC’s No. 1 seed as they travel to San Francisco for a “Monday Night Football” date with the 49ers.

The Monday Night Football matchup between the Lions and the 49ers is airing on ABC and ESPN, so if you have cable or an antenna, all you have to do is change the channel around 8:00 p.m. tonight. If you don’t have cable, the only way to stream Monday Night Football for free is to use a live TV streaming service with a free trial.