Ruben Amorim's side take on Southampton at Old Trafford on Thursday but will be without a key player in the new head coach's system.

The highlight fixture of FA Cup action this weekend kicks off at 10 a.m. ET with Arsenal hosting Manchester United.

Two sides looking to push on from confidence-building wins in the FA Cup meet at Old Trafford on Thursday as Man United host Southampton in the English Premier League. United boss Ruben Amorim will have been delighted by his side's resilience after edging past Arsenal on penalties on Sunday,

I have a lot of admiration for Manchester United's performance in their FA Cup win against Arsenal, especially to grind it out with 10 men for an hour after Diogo Dalot was sent off. I do not want to devalue what United did against Arsenal or Liverpool but they were games where the expectation was not on them to get results.

Ruben Amorim is expecting to find out more about his Manchester United players against Southampton than he did in games with Liverpool and Arsenal. United produced two of the better performances under their new head coach in recent weeks in the 2-2 draw with Liverpool in the Premier League before beating Arsenal in the FA Cup third round,

This evening’s match presents the perfect chance to make a positive start, as they face a Southampton side who sit bottom of the table with just six points so far this season. The Saints’ struggles have continued even since the arrival of new manager Ivan Juric,

Manchester United hope to win their first Premier League match in a month when they host last-place Southampton.