BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK signaling cascade, a signal transduction pathway that transmits mitogenic ...

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma. Our work on the gene and the structure of the BRAF protein ...

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause ... As we have reported, the BRAF and RAS mutant tumors are more sensitive to ERK ...